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The Different Faces of Type 2 Inflammation: Amit and Tzippy’s Stories

On the surface, atopic dermatitis (AD), a chronic skin condition, and asthma, a respiratory disease, may not appear to have much in common, but beneath the surface, both are driven in part by one type of immune response called type 2 inflammation.

Recent scientific developments have shown that excessive type 2 inflammation may underlie different inflammatory diseases (atopic dermatitis, asthma, etc).1,2,3 Due to the unpredictability of these chronic diseases, people like Tzippy and Amit often face uncertainty on a daily basis, not knowing if they will be able to fully participate in school, work or social activities.

Here are their stories.

Growing up with AD: Tzippy

Tzippy has lived with AD since she was a baby. After three hospitalizations while she was a young child, Tzippy’s family traveled all over Europe to try and find relief for her AD symptoms. As an adolescent, she was shy and her disease caused her to feel isolated from her peers, who didn’t understand what she was going through.

Watch how Tzippy is Growing up with AD


Taking Control of Asthma: Amit

Amit had always been active. She did gymnastics when she was young and then as a teenager became an avid runner. When she was 18, Amit began coughing badly after runs and couldn’t catch her breath. She was diagnosed with mild asthma.

Shortly after, Amit joined the army, but her asthma symptoms quickly worsened, and she found herself hospitalized and was diagnosed with severe asthma. She was released from the army and had to miss out on the things she enjoyed doing most like running and socializing with friends.

Since her diagnosis of severe asthma, Amit has learned how to better manage her symptoms with lifestyle modifications and medication. She is studying to become a nurse and says her experience will help her to speak to patients with true empathy and understanding.

Watch how Amit is Taking Control of Asthma


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References

  1. N. A. Gandhi, B. L. Bennett and N. M. Graham. Targeting key proximal drivers of type 2 inflammation in disease. Nature Reviews Drug Discovery. 2016; 15(1):35-50.
  2. S. Carr, E. Chan, and W. Watson. Eosinophilic esophagitis. Allergy, Asthma & Clinical Immunology. 2018; 14(1):58.
  3. J. W. Steinke and J. M. Wilson. Aspirin-exacerbated respiratory disease: pathophysiological insights and clinical advances. Journal of Asthma and Allergy. 2016; 9:37-43.

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